GO:0005085: guanyl-nucleotide exchange factor activity (Molecular function)

"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]

There are 853 sequences with this label.

Enriched clusters

Name	Species	% in cluster	p-value	corrected p-value
Cluster_99	Arabidopsis thaliana	3.54 %	0.0	5e-06
Cluster_141	Zygnema circumcarinatum	3.85 %	0.000181	0.005268
Cluster_308	Zygnema circumcarinatum	50.0 %	0.000793	0.004757
Cluster_77	Zygnema circumcarinatum	3.23 %	0.000257	0.010899

Sequences (853) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !

InterPro Domains

Family Terms

GO:0005085: guanyl-nucleotide exchange factor activity (Molecular function)

Associations