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GO:0140358: P-type transmembrane transporter activity (Molecular function)

"Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and inorganic phosphate (Pi), the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol." [PMID:18075584, PMID:25918123]


There are 470 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_136 Arabidopsis thaliana 4.0 % 0.002511 0.046636
Cluster_364 Arabidopsis thaliana 50.0 % 0.002963 0.035555
Cluster_236 Arabidopsis thaliana 3.77 % 0.002817 0.028482
Cluster_121 Arabidopsis thaliana 1.72 % 0.012856 0.036098
Cluster_169 Arabidopsis thaliana 2.04 % 0.009316 0.029154
Sequences (470) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro Domains

Family Terms