AT4G23450

Description : RING/U-box superfamily protein

Gene families : OG_01_0001143 (OrthoFinder output from Ath, Cre, Mpo, Ppa and Zci) Phylogenetic Tree(s): OG0001143_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: AT4G23450
Cluster	HCCA: Cluster_146

Target	Alias	Description	ECC score	Gene Family Method	Actions
Mp6g04810.1	No alias	E3 ubiquitin-protein ligase At3g02290 OS=Arabidopsis...	0.01	OrthoFinder output from Ath, Cre, Mpo, Ppa and Zci

Type	GO Term	Name	Evidence	Source
BP	GO:0001101	response to acid chemical	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004842	ubiquitin-protein transferase activity	IDA	Interproscan
MF	GO:0005488	binding	None	Extended
MF	GO:0005515	protein binding	IPI	Interproscan
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005634	nucleus	ISM	Interproscan
CC	GO:0005737	cytoplasm	IDA	Interproscan
BP	GO:0006914	autophagy	RCA	Interproscan
BP	GO:0006950	response to stress	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0008270	zinc ion binding	ISS	Interproscan
BP	GO:0009056	catabolic process	None	Extended
BP	GO:0009266	response to temperature stimulus	None	Extended
BP	GO:0009408	response to heat	None	Extended
BP	GO:0009414	response to water deprivation	IMP	Interproscan
BP	GO:0009415	response to water	None	Extended
BP	GO:0009628	response to abiotic stimulus	None	Extended
BP	GO:0009719	response to endogenous stimulus	None	Extended
BP	GO:0009725	response to hormone	None	Extended
BP	GO:0009737	response to abscisic acid	IMP	Interproscan
BP	GO:0009787	regulation of abscisic acid-activated signaling pathway	None	Extended
BP	GO:0009789	positive regulation of abscisic acid-activated signaling pathway	IMP	Interproscan
BP	GO:0009889	regulation of biosynthetic process	None	Extended
BP	GO:0009891	positive regulation of biosynthetic process	None	Extended
BP	GO:0009893	positive regulation of metabolic process	None	Extended
BP	GO:0009966	regulation of signal transduction	None	Extended
BP	GO:0009967	positive regulation of signal transduction	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0010033	response to organic substance	None	Extended
BP	GO:0010035	response to inorganic substance	None	Extended
BP	GO:0010286	heat acclimation	RCA	Interproscan
BP	GO:0010310	regulation of hydrogen peroxide metabolic process	None	Extended
BP	GO:0010646	regulation of cell communication	None	Extended
BP	GO:0010647	positive regulation of cell communication	None	Extended
BP	GO:0010726	positive regulation of hydrogen peroxide metabolic process	None	Extended
BP	GO:0010728	regulation of hydrogen peroxide biosynthetic process	None	Extended
BP	GO:0010729	positive regulation of hydrogen peroxide biosynthetic process	IMP	Interproscan
MF	GO:0016740	transferase activity	None	Extended
BP	GO:0019222	regulation of metabolic process	None	Extended
MF	GO:0019787	ubiquitin-like protein transferase activity	None	Extended
BP	GO:0023051	regulation of signaling	None	Extended
BP	GO:0023056	positive regulation of signaling	None	Extended
BP	GO:0031323	regulation of cellular metabolic process	None	Extended
BP	GO:0031325	positive regulation of cellular metabolic process	None	Extended
BP	GO:0031326	regulation of cellular biosynthetic process	None	Extended
BP	GO:0031328	positive regulation of cellular biosynthetic process	None	Extended
BP	GO:0033993	response to lipid	None	Extended
BP	GO:0042221	response to chemical	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043169	cation binding	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043229	intracellular organelle	None	Extended
CC	GO:0043231	intracellular membrane-bounded organelle	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044248	cellular catabolic process	None	Extended
MF	GO:0046872	metal ion binding	None	Extended
MF	GO:0046914	transition metal ion binding	None	Extended
BP	GO:0048518	positive regulation of biological process	None	Extended
BP	GO:0048522	positive regulation of cellular process	None	Extended
BP	GO:0048583	regulation of response to stimulus	None	Extended
BP	GO:0048584	positive regulation of response to stimulus	None	Extended
BP	GO:0050789	regulation of biological process	None	Extended
BP	GO:0050794	regulation of cellular process	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0061919	process utilizing autophagic mechanism	None	Extended
BP	GO:0065007	biological regulation	None	Extended
BP	GO:0097305	response to alcohol	None	Extended
CC	GO:0110165	cellular anatomical entity	None	Extended
MF	GO:0140096	catalytic activity, acting on a protein	None	Extended
BP	GO:1901419	regulation of response to alcohol	None	Extended
BP	GO:1901700	response to oxygen-containing compound	None	Extended
BP	GO:1903426	regulation of reactive oxygen species biosynthetic process	None	Extended
BP	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	None	Extended
BP	GO:1905957	regulation of cellular response to alcohol	None	Extended
BP	GO:2000377	regulation of reactive oxygen species metabolic process	None	Extended
BP	GO:2000379	positive regulation of reactive oxygen species metabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
CC	GO:0000323	lytic vacuole	IEP	HCCA
BP	GO:0001558	regulation of cell growth	IEP	HCCA
MF	GO:0004022	alcohol dehydrogenase (NAD+) activity	IEP	HCCA
MF	GO:0004031	aldehyde oxidase activity	IEP	HCCA
MF	GO:0004108	citrate (Si)-synthase activity	IEP	HCCA
MF	GO:0004124	cysteine synthase activity	IEP	HCCA
MF	GO:0004175	endopeptidase activity	IEP	HCCA
MF	GO:0004177	aminopeptidase activity	IEP	HCCA
MF	GO:0004197	cysteine-type endopeptidase activity	IEP	HCCA
MF	GO:0004416	hydroxyacylglutathione hydrolase activity	IEP	HCCA
MF	GO:0004557	alpha-galactosidase activity	IEP	HCCA
MF	GO:0004869	cysteine-type endopeptidase inhibitor activity	IEP	HCCA
MF	GO:0005274	allantoin:proton symporter activity	IEP	HCCA
MF	GO:0005350	pyrimidine nucleobase transmembrane transporter activity	IEP	HCCA
MF	GO:0005506	iron ion binding	IEP	HCCA
MF	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	IEP	HCCA
MF	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	IEP	HCCA
CC	GO:0005773	vacuole	IEP	HCCA
CC	GO:0005881	cytoplasmic microtubule	IEP	HCCA
BP	GO:0006082	organic acid metabolic process	IEP	HCCA
BP	GO:0006089	lactate metabolic process	IEP	HCCA
BP	GO:0006099	tricarboxylic acid cycle	IEP	HCCA
BP	GO:0006486	protein glycosylation	IEP	HCCA
BP	GO:0006487	protein N-linked glycosylation	IEP	HCCA
BP	GO:0006508	proteolysis	IEP	HCCA
BP	GO:0006605	protein targeting	IEP	HCCA
BP	GO:0006624	vacuolar protein processing	IEP	HCCA
BP	GO:0006625	protein targeting to peroxisome	IEP	HCCA
BP	GO:0006629	lipid metabolic process	IEP	HCCA
BP	GO:0006631	fatty acid metabolic process	IEP	HCCA
BP	GO:0006635	fatty acid beta-oxidation	IEP	HCCA
BP	GO:0006643	membrane lipid metabolic process	IEP	HCCA
BP	GO:0006661	phosphatidylinositol biosynthetic process	IEP	HCCA
BP	GO:0006664	glycolipid metabolic process	IEP	HCCA
BP	GO:0006672	ceramide metabolic process	IEP	HCCA
BP	GO:0006677	glycosylceramide metabolic process	IEP	HCCA
BP	GO:0006687	glycosphingolipid metabolic process	IEP	HCCA
BP	GO:0006787	porphyrin-containing compound catabolic process	IEP	HCCA
BP	GO:0006807	nitrogen compound metabolic process	IEP	HCCA
BP	GO:0006809	nitric oxide biosynthetic process	IEP	HCCA
BP	GO:0006810	transport	IEP	HCCA
BP	GO:0006812	cation transport	IEP	HCCA
BP	GO:0006816	calcium ion transport	IEP	HCCA
BP	GO:0006886	intracellular protein transport	IEP	HCCA
BP	GO:0006891	intra-Golgi vesicle-mediated transport	IEP	HCCA
BP	GO:0006972	hyperosmotic response	IEP	HCCA
BP	GO:0006996	organelle organization	IEP	HCCA
BP	GO:0007030	Golgi organization	IEP	HCCA
BP	GO:0007031	peroxisome organization	IEP	HCCA
BP	GO:0007568	aging	IEP	HCCA
BP	GO:0008104	protein localization	IEP	HCCA
MF	GO:0008113	peptide-methionine (S)-S-oxide reductase activity	IEP	HCCA
MF	GO:0008233	peptidase activity	IEP	HCCA
MF	GO:0008234	cysteine-type peptidase activity	IEP	HCCA
BP	GO:0009062	fatty acid catabolic process	IEP	HCCA
BP	GO:0009247	glycolipid biosynthetic process	IEP	HCCA
BP	GO:0009267	cellular response to starvation	IEP	HCCA
BP	GO:0009404	toxin metabolic process	IEP	HCCA
BP	GO:0009407	toxin catabolic process	IEP	HCCA
BP	GO:0009438	methylglyoxal metabolic process	IEP	HCCA
BP	GO:0009723	response to ethylene	IEP	HCCA
BP	GO:0009738	abscisic acid-activated signaling pathway	IEP	HCCA
BP	GO:0009755	hormone-mediated signaling pathway	IEP	HCCA
BP	GO:0009962	regulation of flavonoid biosynthetic process	IEP	HCCA
BP	GO:0009963	positive regulation of flavonoid biosynthetic process	IEP	HCCA
MF	GO:0010013	N-1-naphthylphthalamic acid binding	IEP	HCCA
BP	GO:0010150	leaf senescence	IEP	HCCA
BP	GO:0010260	animal organ senescence	IEP	HCCA
MF	GO:0010293	abscisic aldehyde oxidase activity	IEP	HCCA
BP	GO:0010350	cellular response to magnesium starvation	IEP	HCCA
BP	GO:0010351	lithium ion transport	IEP	HCCA
BP	GO:0010498	proteasomal protein catabolic process	IEP	HCCA
BP	GO:0010555	response to mannitol	IEP	HCCA
BP	GO:0010639	negative regulation of organelle organization	IEP	HCCA
BP	GO:0015031	protein transport	IEP	HCCA
MF	GO:0015210	uracil transmembrane transporter activity	IEP	HCCA
MF	GO:0015293	symporter activity	IEP	HCCA
MF	GO:0015294	solute:cation symporter activity	IEP	HCCA
MF	GO:0015295	solute:proton symporter activity	IEP	HCCA
BP	GO:0015720	allantoin transport	IEP	HCCA
BP	GO:0015855	pyrimidine nucleobase transport	IEP	HCCA
BP	GO:0015857	uracil transport	IEP	HCCA
BP	GO:0015919	peroxisomal membrane transport	IEP	HCCA
BP	GO:0015996	chlorophyll catabolic process	IEP	HCCA
BP	GO:0016032	viral process	IEP	HCCA
BP	GO:0016036	cellular response to phosphate starvation	IEP	HCCA
BP	GO:0016042	lipid catabolic process	IEP	HCCA
BP	GO:0016054	organic acid catabolic process	IEP	HCCA
BP	GO:0016137	glycoside metabolic process	IEP	HCCA
BP	GO:0016139	glycoside catabolic process	IEP	HCCA
BP	GO:0016192	vesicle-mediated transport	IEP	HCCA
BP	GO:0016485	protein processing	IEP	HCCA
BP	GO:0016558	protein import into peroxisome matrix	IEP	HCCA
MF	GO:0016623	oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor	IEP	HCCA
MF	GO:0016787	hydrolase activity	IEP	HCCA
BP	GO:0017038	protein import	IEP	HCCA
BP	GO:0018008	N-terminal peptidyl-glycine N-myristoylation	IEP	HCCA
BP	GO:0018201	peptidyl-glycine modification	IEP	HCCA
MF	GO:0018455	alcohol dehydrogenase [NAD(P)+] activity	IEP	HCCA
MF	GO:0018488	aryl-aldehyde oxidase activity	IEP	HCCA
BP	GO:0019243	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione	IEP	HCCA
BP	GO:0019374	galactolipid metabolic process	IEP	HCCA
BP	GO:0019375	galactolipid biosynthetic process	IEP	HCCA
BP	GO:0019377	glycolipid catabolic process	IEP	HCCA
BP	GO:0019395	fatty acid oxidation	IEP	HCCA
BP	GO:0019538	protein metabolic process	IEP	HCCA
BP	GO:0019748	secondary metabolic process	IEP	HCCA
BP	GO:0019752	carboxylic acid metabolic process	IEP	HCCA
BP	GO:0022603	regulation of anatomical structure morphogenesis	IEP	HCCA
BP	GO:0022604	regulation of cell morphogenesis	IEP	HCCA
BP	GO:0030001	metal ion transport	IEP	HCCA
BP	GO:0030149	sphingolipid catabolic process	IEP	HCCA
BP	GO:0030163	protein catabolic process	IEP	HCCA
BP	GO:0030258	lipid modification	IEP	HCCA
BP	GO:0030308	negative regulation of cell growth	IEP	HCCA
BP	GO:0031110	regulation of microtubule polymerization or depolymerization	IEP	HCCA
BP	GO:0031111	negative regulation of microtubule polymerization or depolymerization	IEP	HCCA
BP	GO:0031112	positive regulation of microtubule polymerization or depolymerization	IEP	HCCA
BP	GO:0031113	regulation of microtubule polymerization	IEP	HCCA
BP	GO:0031114	regulation of microtubule depolymerization	IEP	HCCA
BP	GO:0031115	negative regulation of microtubule polymerization	IEP	HCCA
BP	GO:0031117	positive regulation of microtubule depolymerization	IEP	HCCA
BP	GO:0031333	negative regulation of protein-containing complex assembly	IEP	HCCA
MF	GO:0031625	ubiquitin protein ligase binding	IEP	HCCA
BP	GO:0031669	cellular response to nutrient levels	IEP	HCCA
BP	GO:0032026	response to magnesium ion	IEP	HCCA
MF	GO:0032182	ubiquitin-like protein binding	IEP	HCCA
BP	GO:0032271	regulation of protein polymerization	IEP	HCCA
BP	GO:0032272	negative regulation of protein polymerization	IEP	HCCA
BP	GO:0032787	monocarboxylic acid metabolic process	IEP	HCCA
BP	GO:0032886	regulation of microtubule-based process	IEP	HCCA
BP	GO:0033015	tetrapyrrole catabolic process	IEP	HCCA
BP	GO:0033036	macromolecule localization	IEP	HCCA
MF	GO:0033293	monocarboxylic acid binding	IEP	HCCA
BP	GO:0033365	protein localization to organelle	IEP	HCCA
BP	GO:0034440	lipid oxidation	IEP	HCCA
BP	GO:0034605	cellular response to heat	IEP	HCCA
BP	GO:0034613	cellular protein localization	IEP	HCCA
BP	GO:0034622	cellular protein-containing complex assembly	IEP	HCCA
BP	GO:0035864	response to potassium ion	IEP	HCCA
BP	GO:0035865	cellular response to potassium ion	IEP	HCCA
BP	GO:0035966	response to topologically incorrect protein	IEP	HCCA
MF	GO:0036440	citrate synthase activity	IEP	HCCA
BP	GO:0042180	cellular ketone metabolic process	IEP	HCCA
BP	GO:0042182	ketone catabolic process	IEP	HCCA
BP	GO:0042594	response to starvation	IEP	HCCA
BP	GO:0042631	cellular response to water deprivation	IEP	HCCA
BP	GO:0042744	hydrogen peroxide catabolic process	IEP	HCCA
MF	GO:0042887	amide transmembrane transporter activity	IEP	HCCA
BP	GO:0042906	xanthine transport	IEP	HCCA
MF	GO:0042907	xanthine transmembrane transporter activity	IEP	HCCA
MF	GO:0043130	ubiquitin binding	IEP	HCCA
BP	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IEP	HCCA
BP	GO:0043243	positive regulation of protein-containing complex disassembly	IEP	HCCA
BP	GO:0043244	regulation of protein-containing complex disassembly	IEP	HCCA
BP	GO:0043248	proteasome assembly	IEP	HCCA
BP	GO:0043254	regulation of protein-containing complex assembly	IEP	HCCA
MF	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	IEP	HCCA
BP	GO:0043413	macromolecule glycosylation	IEP	HCCA
BP	GO:0043436	oxoacid metabolic process	IEP	HCCA
BP	GO:0043574	peroxisomal transport	IEP	HCCA
BP	GO:0043933	protein-containing complex subunit organization	IEP	HCCA
BP	GO:0044242	cellular lipid catabolic process	IEP	HCCA
BP	GO:0044255	cellular lipid metabolic process	IEP	HCCA
BP	GO:0044282	small molecule catabolic process	IEP	HCCA
MF	GO:0044389	ubiquitin-like protein ligase binding	IEP	HCCA
BP	GO:0044743	protein transmembrane import into intracellular organelle	IEP	HCCA
BP	GO:0044766	multi-organism transport	IEP	HCCA
BP	GO:0045184	establishment of protein localization	IEP	HCCA
MF	GO:0045551	cinnamyl-alcohol dehydrogenase activity	IEP	HCCA
BP	GO:0045926	negative regulation of growth	IEP	HCCA
BP	GO:0046149	pigment catabolic process	IEP	HCCA
BP	GO:0046185	aldehyde catabolic process	IEP	HCCA
BP	GO:0046209	nitric oxide metabolic process	IEP	HCCA
BP	GO:0046395	carboxylic acid catabolic process	IEP	HCCA
BP	GO:0046466	membrane lipid catabolic process	IEP	HCCA
BP	GO:0046477	glycosylceramide catabolic process	IEP	HCCA
BP	GO:0046479	glycosphingolipid catabolic process	IEP	HCCA
BP	GO:0046488	phosphatidylinositol metabolic process	IEP	HCCA
BP	GO:0046514	ceramide catabolic process	IEP	HCCA
BP	GO:0046688	response to copper ion	IEP	HCCA
BP	GO:0046794	transport of virus	IEP	HCCA
BP	GO:0046907	intracellular transport	IEP	HCCA
MF	GO:0046912	acyltransferase, acyl groups converted into alkyl on transfer	IEP	HCCA
BP	GO:0048193	Golgi vesicle transport	IEP	HCCA
CC	GO:0048471	perinuclear region of cytoplasm	IEP	HCCA
BP	GO:0048640	negative regulation of developmental growth	IEP	HCCA
MF	GO:0050302	indole-3-acetaldehyde oxidase activity	IEP	HCCA
BP	GO:0051129	negative regulation of cellular component organization	IEP	HCCA
BP	GO:0051234	establishment of localization	IEP	HCCA
BP	GO:0051494	negative regulation of cytoskeleton organization	IEP	HCCA
BP	GO:0051495	positive regulation of cytoskeleton organization	IEP	HCCA
BP	GO:0051510	regulation of unidimensional cell growth	IEP	HCCA
BP	GO:0051511	negative regulation of unidimensional cell growth	IEP	HCCA
BP	GO:0051592	response to calcium ion	IEP	HCCA
BP	GO:0051596	methylglyoxal catabolic process	IEP	HCCA
BP	GO:0051641	cellular localization	IEP	HCCA
BP	GO:0051649	establishment of localization in cell	IEP	HCCA
BP	GO:0051788	response to misfolded protein	IEP	HCCA
BP	GO:0055085	transmembrane transport	IEP	HCCA
BP	GO:0061727	methylglyoxal catabolic process to lactate	IEP	HCCA
BP	GO:0065002	intracellular protein transmembrane transport	IEP	HCCA
BP	GO:0065003	protein-containing complex assembly	IEP	HCCA
BP	GO:0070085	glycosylation	IEP	HCCA
BP	GO:0070370	cellular heat acclimation	IEP	HCCA
BP	GO:0070507	regulation of microtubule cytoskeleton organization	IEP	HCCA
BP	GO:0070727	cellular macromolecule localization	IEP	HCCA
BP	GO:0070887	cellular response to chemical stimulus	IEP	HCCA
BP	GO:0071214	cellular response to abiotic stimulus	IEP	HCCA
BP	GO:0071216	cellular response to biotic stimulus	IEP	HCCA
BP	GO:0071219	cellular response to molecule of bacterial origin	IEP	HCCA
BP	GO:0071229	cellular response to acid chemical	IEP	HCCA
BP	GO:0071280	cellular response to copper ion	IEP	HCCA
BP	GO:0071286	cellular response to magnesium ion	IEP	HCCA
BP	GO:0071322	cellular response to carbohydrate stimulus	IEP	HCCA
BP	GO:0071325	cellular response to mannitol stimulus	IEP	HCCA
BP	GO:0071462	cellular response to water stimulus	IEP	HCCA
BP	GO:0071704	organic substance metabolic process	IEP	HCCA
BP	GO:0071806	protein transmembrane transport	IEP	HCCA
BP	GO:0072329	monocarboxylic acid catabolic process	IEP	HCCA
BP	GO:0072594	establishment of protein localization to organelle	IEP	HCCA
BP	GO:0072662	protein localization to peroxisome	IEP	HCCA
BP	GO:0072663	establishment of protein localization to peroxisome	IEP	HCCA
BP	GO:0072708	response to sorbitol	IEP	HCCA
BP	GO:0072709	cellular response to sorbitol	IEP	HCCA
BP	GO:0075733	intracellular transport of virus	IEP	HCCA
MF	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	IEP	HCCA
BP	GO:0080129	proteasome core complex assembly	IEP	HCCA
BP	GO:0090693	plant organ senescence	IEP	HCCA
BP	GO:0098754	detoxification	IEP	HCCA
BP	GO:0104004	cellular response to environmental stimulus	IEP	HCCA
BP	GO:1901564	organonitrogen compound metabolic process	IEP	HCCA
BP	GO:1901565	organonitrogen compound catabolic process	IEP	HCCA
BP	GO:1901575	organic substance catabolic process	IEP	HCCA
BP	GO:1901615	organic hydroxy compound metabolic process	IEP	HCCA
BP	GO:1901701	cellular response to oxygen-containing compound	IEP	HCCA
BP	GO:1901879	regulation of protein depolymerization	IEP	HCCA
BP	GO:1901881	positive regulation of protein depolymerization	IEP	HCCA
MF	GO:1901981	phosphatidylinositol phosphate binding	IEP	HCCA
BP	GO:1902579	multi-organism localization	IEP	HCCA
BP	GO:1902904	negative regulation of supramolecular fiber organization	IEP	HCCA
BP	GO:1902905	positive regulation of supramolecular fiber organization	IEP	HCCA
MF	GO:1902936	phosphatidylinositol bisphosphate binding	IEP	HCCA
BP	GO:1903509	liposaccharide metabolic process	IEP	HCCA
BP	GO:2001057	reactive nitrogen species metabolic process	IEP	HCCA

InterPro domains	Description	Start	Stop
IPR001841	Znf_RING	102	144

External Links

PLAZA 3.0 Dicots	AT4G23450

AT4G23450

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation