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GO:0016592: mediator complex (Cellular component)

"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]


There are 1695 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_139 Arabidopsis thaliana 2.2 % 0.004387 0.036049
Cluster_221 Arabidopsis thaliana 1.82 % 0.006342 0.028401
Cluster_131 Arabidopsis thaliana 3.45 % 0.000115 0.01349
Cluster_58 Chlamydomonas reinhardtii 1.79 % 0.018793 0.047307
Cluster_205 Physcomitrella patens 2.86 % 6.8e-05 0.003043
Cluster_170 Zygnema circumcarinatum 1.92 % 0.001153 0.010297
Cluster_119 Zygnema circumcarinatum 1.67 % 0.00153 0.01188
Sequences (1695) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro Domains

Family Terms