AT2G30550

Description : alpha/beta-Hydrolases superfamily protein

Gene families : OG_01_0000228 (OrthoFinder output from Ath, Cre, Mpo, Ppa and Zci) Phylogenetic Tree(s): OG0000228_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: AT2G30550
Cluster	HCCA: Cluster_120

Target	Alias	Description	ECC score	Gene Family Method
AT1G06800	No alias	alpha/beta-Hydrolases superfamily protein	0.01	OrthoFinder output from Ath, Cre, Mpo, Ppa and Zci
AT1G30370	No alias	alpha/beta-Hydrolases superfamily protein	0.05	OrthoFinder output from Ath, Cre, Mpo, Ppa and Zci
AT2G31690	No alias	alpha/beta-Hydrolases superfamily protein	0.05	OrthoFinder output from Ath, Cre, Mpo, Ppa and Zci
Cre09.g391986	No alias	Phospholipase A1-Igamma1, chloroplastic OS=Arabidopsis thaliana	0.01	OrthoFinder output from Ath, Cre, Mpo, Ppa and Zci

Type	GO Term	Name	Evidence	Source
BP	GO:0001101	response to acid chemical	None	Extended
BP	GO:0002376	immune system process	None	Extended
BP	GO:0002682	regulation of immune system process	None	Extended
BP	GO:0002831	regulation of response to biotic stimulus	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004620	phospholipase activity	None	Extended
MF	GO:0004806	triglyceride lipase activity	IDA	Interproscan
MF	GO:0004806	triglyceride lipase activity	ISS	Interproscan
CC	GO:0005575	cellular_component	None	Extended
BP	GO:0006082	organic acid metabolic process	None	Extended
BP	GO:0006605	protein targeting	None	Extended
BP	GO:0006612	protein targeting to membrane	RCA	Interproscan
BP	GO:0006629	lipid metabolic process	ISS	Interproscan
BP	GO:0006643	membrane lipid metabolic process	None	Extended
BP	GO:0006664	glycolipid metabolic process	None	Extended
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006810	transport	None	Extended
BP	GO:0006886	intracellular protein transport	None	Extended
BP	GO:0006950	response to stress	None	Extended
BP	GO:0006952	defense response	None	Extended
BP	GO:0006955	immune response	None	Extended
BP	GO:0007154	cell communication	None	Extended
BP	GO:0007165	signal transduction	None	Extended
BP	GO:0008104	protein localization	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0008610	lipid biosynthetic process	None	Extended
MF	GO:0008970	phospholipase A1 activity	IDA	Interproscan
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009247	glycolipid biosynthetic process	None	Extended
BP	GO:0009267	cellular response to starvation	None	Extended
BP	GO:0009414	response to water deprivation	None	Extended
BP	GO:0009415	response to water	None	Extended
CC	GO:0009507	chloroplast	IDA	Interproscan
CC	GO:0009507	chloroplast	ISM	Interproscan
CC	GO:0009536	plastid	None	Extended
BP	GO:0009605	response to external stimulus	None	Extended
BP	GO:0009607	response to biotic stimulus	None	Extended
BP	GO:0009628	response to abiotic stimulus	None	Extended
BP	GO:0009696	salicylic acid metabolic process	None	Extended
BP	GO:0009697	salicylic acid biosynthetic process	RCA	Interproscan
BP	GO:0009755	hormone-mediated signaling pathway	None	Extended
BP	GO:0009863	salicylic acid mediated signaling pathway	RCA	Interproscan
BP	GO:0009867	jasmonic acid mediated signaling pathway	RCA	Interproscan
BP	GO:0009987	cellular process	None	Extended
BP	GO:0009991	response to extracellular stimulus	None	Extended
BP	GO:0010035	response to inorganic substance	None	Extended
BP	GO:0010363	regulation of plant-type hypersensitive response	RCA	Interproscan
BP	GO:0010941	regulation of cell death	None	Extended
BP	GO:0015031	protein transport	None	Extended
BP	GO:0016036	cellular response to phosphate starvation	RCA	Interproscan
BP	GO:0016053	organic acid biosynthetic process	None	Extended
MF	GO:0016298	lipase activity	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016788	hydrolase activity, acting on ester bonds	None	Extended
BP	GO:0018958	phenol-containing compound metabolic process	None	Extended
BP	GO:0019374	galactolipid metabolic process	None	Extended
BP	GO:0019375	galactolipid biosynthetic process	RCA	Interproscan
BP	GO:0019438	aromatic compound biosynthetic process	None	Extended
BP	GO:0019752	carboxylic acid metabolic process	None	Extended
BP	GO:0031347	regulation of defense response	None	Extended
BP	GO:0031348	negative regulation of defense response	RCA	Interproscan
BP	GO:0031667	response to nutrient levels	None	Extended
BP	GO:0031668	cellular response to extracellular stimulus	None	Extended
BP	GO:0031669	cellular response to nutrient levels	None	Extended
BP	GO:0032101	regulation of response to external stimulus	None	Extended
BP	GO:0032787	monocarboxylic acid metabolic process	None	Extended
BP	GO:0033036	macromolecule localization	None	Extended
BP	GO:0033554	cellular response to stress	None	Extended
BP	GO:0034613	cellular protein localization	None	Extended
BP	GO:0042221	response to chemical	None	Extended
BP	GO:0042537	benzene-containing compound metabolic process	None	Extended
BP	GO:0042594	response to starvation	None	Extended
BP	GO:0042631	cellular response to water deprivation	RCA	Interproscan
BP	GO:0043067	regulation of programmed cell death	None	Extended
BP	GO:0043207	response to external biotic stimulus	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043229	intracellular organelle	None	Extended
CC	GO:0043231	intracellular membrane-bounded organelle	None	Extended
BP	GO:0043436	oxoacid metabolic process	None	Extended
BP	GO:0043903	regulation of biological process involved in symbiotic interaction	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044255	cellular lipid metabolic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
BP	GO:0044283	small molecule biosynthetic process	None	Extended
BP	GO:0044419	biological process involved in interspecies interaction between organisms	None	Extended
BP	GO:0045087	innate immune response	RCA	Interproscan
BP	GO:0045088	regulation of innate immune response	None	Extended
BP	GO:0045184	establishment of protein localization	None	Extended
BP	GO:0046189	phenol-containing compound biosynthetic process	None	Extended
BP	GO:0046394	carboxylic acid biosynthetic process	None	Extended
BP	GO:0046467	membrane lipid biosynthetic process	None	Extended
BP	GO:0046907	intracellular transport	None	Extended
MF	GO:0047714	galactolipase activity	IDA	Interproscan
BP	GO:0048519	negative regulation of biological process	None	Extended
BP	GO:0048583	regulation of response to stimulus	None	Extended
BP	GO:0048585	negative regulation of response to stimulus	None	Extended
BP	GO:0050776	regulation of immune response	None	Extended
BP	GO:0050789	regulation of biological process	None	Extended
BP	GO:0050794	regulation of cellular process	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0051179	localization	None	Extended
BP	GO:0051234	establishment of localization	None	Extended
BP	GO:0051641	cellular localization	None	Extended
BP	GO:0051649	establishment of localization in cell	None	Extended
BP	GO:0051668	localization within membrane	None	Extended
BP	GO:0051707	response to other organism	None	Extended
BP	GO:0051716	cellular response to stimulus	None	Extended
MF	GO:0052689	carboxylic ester hydrolase activity	None	Extended
BP	GO:0065007	biological regulation	None	Extended
BP	GO:0070727	cellular macromolecule localization	None	Extended
BP	GO:0070887	cellular response to chemical stimulus	None	Extended
BP	GO:0071214	cellular response to abiotic stimulus	None	Extended
BP	GO:0071229	cellular response to acid chemical	None	Extended
BP	GO:0071462	cellular response to water stimulus	None	Extended
BP	GO:0071496	cellular response to external stimulus	None	Extended
BP	GO:0071702	organic substance transport	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0071705	nitrogen compound transport	None	Extended
BP	GO:0072330	monocarboxylic acid biosynthetic process	None	Extended
BP	GO:0072657	protein localization to membrane	None	Extended
BP	GO:0080134	regulation of response to stress	None	Extended
BP	GO:0080135	regulation of cellular response to stress	None	Extended
BP	GO:0090150	establishment of protein localization to membrane	None	Extended
BP	GO:0098542	defense response to other organism	None	Extended
BP	GO:0104004	cellular response to environmental stimulus	None	Extended
CC	GO:0110165	cellular anatomical entity	None	Extended
BP	GO:1901135	carbohydrate derivative metabolic process	None	Extended
BP	GO:1901137	carbohydrate derivative biosynthetic process	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
BP	GO:1901362	organic cyclic compound biosynthetic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended
BP	GO:1901615	organic hydroxy compound metabolic process	None	Extended
BP	GO:1901617	organic hydroxy compound biosynthetic process	None	Extended
BP	GO:1901700	response to oxygen-containing compound	None	Extended
BP	GO:1901701	cellular response to oxygen-containing compound	None	Extended
BP	GO:1903509	liposaccharide metabolic process	None	Extended

Toggle parental

Type	GO Term	Name	Evidence	Source
BP	GO:0000162	tryptophan biosynthetic process	IEP	HCCA
BP	GO:0000165	MAPK cascade	IEP	HCCA
BP	GO:0001666	response to hypoxia	IEP	HCCA
BP	GO:0002218	activation of innate immune response	IEP	HCCA
BP	GO:0002237	response to molecule of bacterial origin	IEP	HCCA
BP	GO:0002252	immune effector process	IEP	HCCA
BP	GO:0002253	activation of immune response	IEP	HCCA
BP	GO:0002679	respiratory burst involved in defense response	IEP	HCCA
BP	GO:0002684	positive regulation of immune system process	IEP	HCCA
BP	GO:0002833	positive regulation of response to biotic stimulus	IEP	HCCA
MF	GO:0004049	anthranilate synthase activity	IEP	HCCA
MF	GO:0004144	diacylglycerol O-acyltransferase activity	IEP	HCCA
MF	GO:0004252	serine-type endopeptidase activity	IEP	HCCA
MF	GO:0004425	indole-3-glycerol-phosphate synthase activity	IEP	HCCA
MF	GO:0004551	nucleotide diphosphatase activity	IEP	HCCA
MF	GO:0004568	chitinase activity	IEP	HCCA
MF	GO:0004664	prephenate dehydratase activity	IEP	HCCA
MF	GO:0004838	L-tyrosine:2-oxoglutarate aminotransferase activity	IEP	HCCA
CC	GO:0005950	anthranilate synthase complex	IEP	HCCA
BP	GO:0006558	L-phenylalanine metabolic process	IEP	HCCA
BP	GO:0006566	threonine metabolic process	IEP	HCCA
BP	GO:0006567	threonine catabolic process	IEP	HCCA
BP	GO:0006568	tryptophan metabolic process	IEP	HCCA
BP	GO:0006569	tryptophan catabolic process	IEP	HCCA
BP	GO:0006586	indolalkylamine metabolic process	IEP	HCCA
BP	GO:0006641	triglyceride metabolic process	IEP	HCCA
BP	GO:0006766	vitamin metabolic process	IEP	HCCA
BP	GO:0006775	fat-soluble vitamin metabolic process	IEP	HCCA
BP	GO:0006865	amino acid transport	IEP	HCCA
BP	GO:0006972	hyperosmotic response	IEP	HCCA
BP	GO:0006984	ER-nucleus signaling pathway	IEP	HCCA
MF	GO:0008131	primary amine oxidase activity	IEP	HCCA
BP	GO:0008652	cellular amino acid biosynthetic process	IEP	HCCA
MF	GO:0008909	isochorismate synthase activity	IEP	HCCA
BP	GO:0009063	cellular amino acid catabolic process	IEP	HCCA
BP	GO:0009072	aromatic amino acid family metabolic process	IEP	HCCA
BP	GO:0009073	aromatic amino acid family biosynthetic process	IEP	HCCA
BP	GO:0009074	aromatic amino acid family catabolic process	IEP	HCCA
BP	GO:0009094	L-phenylalanine biosynthetic process	IEP	HCCA
BP	GO:0009095	aromatic amino acid family biosynthetic process, prephenate pathway	IEP	HCCA
BP	GO:0009110	vitamin biosynthetic process	IEP	HCCA
BP	GO:0009266	response to temperature stimulus	IEP	HCCA
BP	GO:0009308	amine metabolic process	IEP	HCCA
BP	GO:0009309	amine biosynthetic process	IEP	HCCA
BP	GO:0009403	toxin biosynthetic process	IEP	HCCA
BP	GO:0009404	toxin metabolic process	IEP	HCCA
BP	GO:0009409	response to cold	IEP	HCCA
BP	GO:0009581	detection of external stimulus	IEP	HCCA
BP	GO:0009595	detection of biotic stimulus	IEP	HCCA
BP	GO:0009617	response to bacterium	IEP	HCCA
BP	GO:0009620	response to fungus	IEP	HCCA
BP	GO:0009625	response to insect	IEP	HCCA
BP	GO:0009626	plant-type hypersensitive response	IEP	HCCA
BP	GO:0009627	systemic acquired resistance	IEP	HCCA
BP	GO:0009636	response to toxic substance	IEP	HCCA
BP	GO:0009651	response to salt stress	IEP	HCCA
BP	GO:0009683	indoleacetic acid metabolic process	IEP	HCCA
BP	GO:0009684	indoleacetic acid biosynthetic process	IEP	HCCA
BP	GO:0009700	indole phytoalexin biosynthetic process	IEP	HCCA
BP	GO:0009719	response to endogenous stimulus	IEP	HCCA
BP	GO:0009725	response to hormone	IEP	HCCA
BP	GO:0009738	abscisic acid-activated signaling pathway	IEP	HCCA
BP	GO:0009759	indole glucosinolate biosynthetic process	IEP	HCCA
BP	GO:0009823	cytokinin catabolic process	IEP	HCCA
BP	GO:0009850	auxin metabolic process	IEP	HCCA
BP	GO:0009851	auxin biosynthetic process	IEP	HCCA
BP	GO:0009862	systemic acquired resistance, salicylic acid mediated signaling pathway	IEP	HCCA
BP	GO:0009864	induced systemic resistance, jasmonic acid mediated signaling pathway	IEP	HCCA
BP	GO:0009890	negative regulation of biosynthetic process	IEP	HCCA
BP	GO:0010033	response to organic substance	IEP	HCCA
BP	GO:0010112	regulation of systemic acquired resistance	IEP	HCCA
BP	GO:0010120	camalexin biosynthetic process	IEP	HCCA
BP	GO:0010188	response to microbial phytotoxin	IEP	HCCA
BP	GO:0010200	response to chitin	IEP	HCCA
BP	GO:0010243	response to organonitrogen compound	IEP	HCCA
BP	GO:0010310	regulation of hydrogen peroxide metabolic process	IEP	HCCA
BP	GO:0010558	negative regulation of macromolecule biosynthetic process	IEP	HCCA
BP	GO:0010618	aerenchyma formation	IEP	HCCA
BP	GO:0012501	programmed cell death	IEP	HCCA
BP	GO:0015849	organic acid transport	IEP	HCCA
BP	GO:0016045	detection of bacterium	IEP	HCCA
MF	GO:0016301	kinase activity	IEP	HCCA
MF	GO:0016411	acylglycerol O-acyltransferase activity	IEP	HCCA
MF	GO:0016830	carbon-carbon lyase activity	IEP	HCCA
MF	GO:0016833	oxo-acid-lyase activity	IEP	HCCA
MF	GO:0019139	cytokinin dehydrogenase activity	IEP	HCCA
BP	GO:0019220	regulation of phosphate metabolic process	IEP	HCCA
BP	GO:0019222	regulation of metabolic process	IEP	HCCA
BP	GO:0019432	triglyceride biosynthetic process	IEP	HCCA
BP	GO:0019684	photosynthesis, light reaction	IEP	HCCA
BP	GO:0019748	secondary metabolic process	IEP	HCCA
BP	GO:0030968	endoplasmic reticulum unfolded protein response	IEP	HCCA
BP	GO:0031323	regulation of cellular metabolic process	IEP	HCCA
BP	GO:0031327	negative regulation of cellular biosynthetic process	IEP	HCCA
BP	GO:0031399	regulation of protein modification process	IEP	HCCA
BP	GO:0032268	regulation of cellular protein metabolic process	IEP	HCCA
BP	GO:0033306	phytol metabolic process	IEP	HCCA
BP	GO:0033993	response to lipid	IEP	HCCA
BP	GO:0034050	programmed cell death induced by symbiont	IEP	HCCA
BP	GO:0034308	primary alcohol metabolic process	IEP	HCCA
BP	GO:0034614	cellular response to reactive oxygen species	IEP	HCCA
BP	GO:0034754	cellular hormone metabolic process	IEP	HCCA
BP	GO:0034976	response to endoplasmic reticulum stress	IEP	HCCA
BP	GO:0035303	regulation of dephosphorylation	IEP	HCCA
BP	GO:0035304	regulation of protein dephosphorylation	IEP	HCCA
MF	GO:0035529	NADH pyrophosphatase activity	IEP	HCCA
BP	GO:0035556	intracellular signal transduction	IEP	HCCA
BP	GO:0036293	response to decreased oxygen levels	IEP	HCCA
BP	GO:0036294	cellular response to decreased oxygen levels	IEP	HCCA
BP	GO:0042181	ketone biosynthetic process	IEP	HCCA
BP	GO:0042343	indole glucosinolate metabolic process	IEP	HCCA
BP	GO:0042362	fat-soluble vitamin biosynthetic process	IEP	HCCA
BP	GO:0042371	vitamin K biosynthetic process	IEP	HCCA
BP	GO:0042372	phylloquinone biosynthetic process	IEP	HCCA
BP	GO:0042373	vitamin K metabolic process	IEP	HCCA
BP	GO:0042374	phylloquinone metabolic process	IEP	HCCA
BP	GO:0042401	cellular biogenic amine biosynthetic process	IEP	HCCA
BP	GO:0042430	indole-containing compound metabolic process	IEP	HCCA
BP	GO:0042435	indole-containing compound biosynthetic process	IEP	HCCA
BP	GO:0042436	indole-containing compound catabolic process	IEP	HCCA
BP	GO:0042445	hormone metabolic process	IEP	HCCA
BP	GO:0042447	hormone catabolic process	IEP	HCCA
BP	GO:0042538	hyperosmotic salinity response	IEP	HCCA
BP	GO:0042742	defense response to bacterium	IEP	HCCA
BP	GO:0043069	negative regulation of programmed cell death	IEP	HCCA
BP	GO:0043090	amino acid import	IEP	HCCA
BP	GO:0043900	obsolete regulation of multi-organism process	IEP	HCCA
BP	GO:0044403	biological process involved in symbiotic interaction	IEP	HCCA
BP	GO:0045089	positive regulation of innate immune response	IEP	HCCA
BP	GO:0045454	cell redox homeostasis	IEP	HCCA
BP	GO:0045730	respiratory burst	IEP	HCCA
BP	GO:0045892	negative regulation of transcription, DNA-templated	IEP	HCCA
BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	IEP	HCCA
BP	GO:0046217	indole phytoalexin metabolic process	IEP	HCCA
BP	GO:0046218	indolalkylamine catabolic process	IEP	HCCA
BP	GO:0046219	indolalkylamine biosynthetic process	IEP	HCCA
BP	GO:0046460	neutral lipid biosynthetic process	IEP	HCCA
BP	GO:0046463	acylglycerol biosynthetic process	IEP	HCCA
MF	GO:0047617	acyl-CoA hydrolase activity	IEP	HCCA
MF	GO:0047631	ADP-ribose diphosphatase activity	IEP	HCCA
MF	GO:0047769	arogenate dehydratase activity	IEP	HCCA
CC	GO:0048046	apoplast	IEP	HCCA
BP	GO:0048523	negative regulation of cellular process	IEP	HCCA
BP	GO:0048584	positive regulation of response to stimulus	IEP	HCCA
MF	GO:0050486	intramolecular transferase activity, transferring hydroxy groups	IEP	HCCA
BP	GO:0050778	positive regulation of immune response	IEP	HCCA
BP	GO:0050832	defense response to fungus	IEP	HCCA
BP	GO:0051172	negative regulation of nitrogen compound metabolic process	IEP	HCCA
BP	GO:0051174	regulation of phosphorus metabolic process	IEP	HCCA
BP	GO:0051246	regulation of protein metabolic process	IEP	HCCA
BP	GO:0051253	negative regulation of RNA metabolic process	IEP	HCCA
MF	GO:0051287	NAD binding	IEP	HCCA
BP	GO:0051606	detection of stimulus	IEP	HCCA
BP	GO:0051702	biological process involved in interaction with symbiont	IEP	HCCA
BP	GO:0052033	obsolete pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response	IEP	HCCA
BP	GO:0052314	phytoalexin metabolic process	IEP	HCCA
BP	GO:0052315	phytoalexin biosynthetic process	IEP	HCCA
BP	GO:0052317	camalexin metabolic process	IEP	HCCA
BP	GO:0060548	negative regulation of cell death	IEP	HCCA
BP	GO:0065008	regulation of biological quality	IEP	HCCA
BP	GO:0070301	cellular response to hydrogen peroxide	IEP	HCCA
BP	GO:0070482	response to oxygen levels	IEP	HCCA
MF	GO:0070547	L-tyrosine aminotransferase activity	IEP	HCCA
BP	GO:0071453	cellular response to oxygen levels	IEP	HCCA
BP	GO:0071456	cellular response to hypoxia	IEP	HCCA
BP	GO:0080151	positive regulation of salicylic acid mediated signaling pathway	IEP	HCCA
BP	GO:0080183	response to photooxidative stress	IEP	HCCA
BP	GO:0098543	detection of other organism	IEP	HCCA
BP	GO:0098581	detection of external biotic stimulus	IEP	HCCA
BP	GO:1900055	regulation of leaf senescence	IEP	HCCA
BP	GO:1900056	negative regulation of leaf senescence	IEP	HCCA
BP	GO:1901606	alpha-amino acid catabolic process	IEP	HCCA
BP	GO:1901661	quinone metabolic process	IEP	HCCA
BP	GO:1901663	quinone biosynthetic process	IEP	HCCA
BP	GO:1901698	response to nitrogen compound	IEP	HCCA
BP	GO:1902221	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process	IEP	HCCA
BP	GO:1902223	erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process	IEP	HCCA
BP	GO:1902679	negative regulation of RNA biosynthetic process	IEP	HCCA
BP	GO:1903173	fatty alcohol metabolic process	IEP	HCCA
BP	GO:1903507	negative regulation of nucleic acid-templated transcription	IEP	HCCA
BP	GO:2000031	regulation of salicylic acid mediated signaling pathway	IEP	HCCA
BP	GO:2000113	negative regulation of cellular macromolecule biosynthetic process	IEP	HCCA
BP	GO:2000377	regulation of reactive oxygen species metabolic process	IEP	HCCA

InterPro domains	Description	Start	Stop
IPR002921	Fungal_lipase-like	229	389

External Links

PLAZA 3.0 Dicots	AT2G30550

AT2G30550

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation